United Kingdom Prospective Diabetes Study (UKPDS): what now or so what?

Participating in the United Kingdom Prospective Diabetes Study (UKPDS): a qualitative study of patients' experiences.

The United Kingdom Prospective Diabetes Study (UKPDS) is one of the longest and largest clinical trials ever conducted. It explored the effects of intensive blood glucose and blood pressure control on the development of complications in patients with type 2 diabetes. Patients took part in this trial for up to 20 years and the drop-out rate was extremely low. The aim of this discussion paper is ...

Diastolic heart failure: what, so what and now what?

The Elephant in the Room Until two decades ago, the notion that heart failure (HF) could occur in the presence of normal ejection fraction (EF) was met with great skepticism. While most physicians could recall encounters with hypertensive elderly ladies in acute pulmonary oedema despite a normal EF, it was not until large epidemiologic studies provided evidence for the existence of this syndrom...

Seeing what you want to see in randomised controlled trials: versions and perversions of UKPDS data. United Kingdom prospective diabetes study.

Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79.

BACKGROUND We aimed to determine the prevalence of silent myocardial infarction (SMI) in people with newly diagnosed type 2 diabetes mellitus and its relationships to future myocardial infarction (MI) and all-cause mortality. METHODS AND RESULTS We examined data from the 5102 patients in the 30-year UK Prospective Diabetes Study (UKPDS) and used Cox proportional hazards regression to examine ...

Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).

BACKGROUND The progression of nephropathy from diagnosis of type 2 diabetes has not been well described from a single population. This study sought to describe the development and progression through the stages of microalbuminuria, macroalbuminuria, persistently elevated plasma creatinine or renal replacement therapy (RRT), and death. METHODS Using observed and modeled data from 5097 subjects...